Location: New Haven, CT

Position Summary :

• The Development Scientist I is responsible for leading and executing efforts for cell line development and upstream process development to support pre-clinical, early, and late phase programs.
• This position is expected to require >75% of the time supporting in laboratory activities.
• The ideal candidate will have in-depth of knowledge of mammalian transfection, single cell cloning, and mammalian cell culture.
• Experience with upstream process development is also desired. The candidate is expected to lead small teams, perform detailed scientific research, execute experiments, analyze experimental data, provide recommendations to improve efficiency of process workflows, and improve robustness while ensuring regulatory compliance.
• The Development Scientist I will support teams in a cross-functional environment, collaborating with other members of Global Product Development.

Principal Responsibilities :

• Lead efforts to design and conduct experiments and apply methods for the generation and cloning of mammalian cell lines (30%)Support development and optimization of robust and scalable upstream processes for GMP manufacturing of biologic for clinical supply (20%)Act as a technical expert in mammalian transfection, routine cell culture, single cell cloning, and bank preparation in collaboration with cross-functional teams (20%) Lead team efforts to seek out and evaluate novel technologies to enhance cell line development and cell culture process development (15%) .
• Author technical protocols, reports and peer-reviewed external journal articles (10%)Communicate findings to colleagues within the group through informal and formal presentations (5%) .

Qualifications:

• The Scientist I, Upstream Development should have:Expertise in mammalian transfection, single cell cloning, and cell cultureTechnical proficiency with laboratory automation and high throughput technologies .
• Proven ability to prioritize between projects and allocating effort accordingly and assisting others in similar assessmentsMust have demonstrated technical proficiency, scientific creativity, strong leadership, advanced problem solving skills, and strong capability to collaborate with othersGood oral and written communication skills are essential with experience in writing and reviewing technical reports supporting regulatory filings .
• Excellent collaboration skills and experience working in cross functional teamsAbility to conduct critical evaluation of scientific documentation and testing dataExperience in Lean Six Sigma or equivalent methodologies is desired Education .
• A successful candidate will typically hold a Ph.D. in Chemistry / Chemical Engineering / Biochemical Engineering or related fields with 0 2 years of experience, a M.S. in related fields with 6+ years of experience, or B.S in related fields with 8+ years of experience in biotechnology or the pharmaceutical industry.

CompetenciesThe candidate must demonstrate the following competencies:

Decision Quality: Solves complex technical problems as part of a teamScientific Inquisitiveness: Understands background of assigned technical tasks and can identify and evaluate improvements to existing approachesCollaborates: Discusses work with supervisor and coworkers; Can draft technical documents with templatesEnsures Accountability: Understands priority of assigned tasks with minimal supervision and ensures individual and team tasks are completedTechnical expertise: Deep knowledge of cell culture principles applicable to transfection and cloning